Committee for Veterinary Medicinal Products Thiomersal and Timerfonate Summary Report

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2. Thiomersal and timerfonate are organomercuric compounds used as preservatives in vaccines, antigens and immunoglobulins intended for use in humans and animals. At present these substances seem to best fulfil the requirements for efficacious preservatives used in inactivated vaccines because they do not react with antigen and are effective at very low concentrations. According to the recent survey, 73% of inactivated multidose vaccines for food-producing animals marketed in European Union contain thiomersal as preservative. In addition the substances have a limited use in veterinary preparations for injection.

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An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2014. Reproduction is authorised provided the source is acknowledged. 20 November 2014 EMA/CHMP/ CVMP/ SWP/169430/2012 Committee for Medicinal Products for Human Use (CHMP) Committee for Medicinal Products for Veterina...

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Committee for Veterinary Medicinal Products

Article 4 of Council Directive 81/851/EEC requires that a Member State shall not authorise the placing on the market of a veterinary medicinal product intended for administration to food producing animals [...] unless the active substance [...] contained in the product: a) were authorised for use in other veterinary medicinal products in the Member State concerned on the day of entry into force...

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تاریخ انتشار 1997